| He's Just Not That Into You | Mary |
| Noche desesperada, La | Danielle De Barbarac |
| Beverly Hills Chihuahua | Chloe (voice) |
| The 64th Annual Golden Globe Awards | Herself - Presenter |
| Hollywood's Most Powerful Women | Herself |
| Live from the Red Carpet: The 2007 Golden Globe Awards | Herself |
| Cómo conseguir un papel en Hollywood | Herself (archive footage) |
| Penélope, camino a los Oscar | Herself (archive footage) (uncredited) |
| The Gershwin Gala | Herself |
| The Child Star Jinx | Herself |
| "Famous" | Herself (archive footage) |
| Maquillando entre monstruos | Gertie (archive footage) |
| The 34th Annual People's Choice Awards | Herself |
| Whip It! | |
| Most Shocking Celebrity Moments of the 80s | Herself (archive footage) |
| Oscar, que empiece el espectáculo | Herself (archive footage) (uncredited) |
| "Saturday Night Live" | Herself / ... (8 episodes, 1982-2007) |
| Suddenly, Love | Bobbi Graham (uncredited) |
| Altered States | Margaret Jessup |
| Bogie | Leslie Bogart |
| "Entertainment Tonight" | Herself (3 episodes, 2007-2008) |
| "Wogan" | (3 episodes, 1985-1990) |
| E.T.: The Extra-Terrestrial | Gertie |
| EPCOT Center: The Opening Celebration | Herself |
| Firestarter | Charlene 'Charlie' McGee |
| Irreconcilable Differences | Casey Brodsky |
| Cat's Eye | Our Girl, Amanda (all segments) |
| "The Oprah Winfrey Show" | Herself (3 episodes, 2004-2008) |
| Babes in Toyland | Lisa Piper |
| A Conspiracy of Love | Jody Woldarski |
| "Live with Regis and Kathie Lee" | Herself (3 episodes, 2004-2007) |
| Far from Home | Joleen Cox |
| See You in the Morning | Cathy Goodwin |
| "2000 Malibu Road" | Lindsay Rule (6 episodes, 1992) |
| "The Tonight Show with Jay Leno" | Herself (5 episodes, 2001-2007) |
| Guncrazy | Anita Minteer |
| Motorama | Fantasy Girl |
| No Place to Hide | Tinsel Hanley |
| Poison Ivy | Ivy |
| Sketch Artist | Daisy Drew |
| Waxwork II: Lost in Time | Vampire Victim #1 |
| "Late Night with Conan O'Brien" | Herself (6 episodes, 1993-2007) |
| "Late Show with David Letterman" | Herself (5 episodes, 1996-2007) |
| The Amy Fisher Story | Amy Fisher |
| Doppelganger | Holly Gooding |
| Wayne's World 2 | Bjergen Kjergen |
| Bad Girls | Lilly Laronette |
| Inside the Goldmine | Daisy |
| "Mad TV" | Herself (2 episodes, 2000-2001) |
| Batman Forever | Sugar |
| Boys on the Side | Holly Pulchik-Lincoln |
| Mad Love | Casey Roberts |
| "The Daily Show" | Herself (3 episodes, 2004-2005) |
| "The Rosie O'Donnell Show" | Herself (6 episodes, 1996-2000) |
| Everyone Says I Love You | Skylar Dandridge |
| Scream | Casey Becker |
| Best Men | Hope |
| Home Fries | Sally Jackson |
| Wishful Thinking | Lena |
| Ever After | Danielle De Barbarac |
| The Wedding Singer | Julia |
| Titan A.E. | Akima |
| Never Been Kissed | Josie Geller |
| Charlie's Angels | Dylan Sanders |
| "The Tom Green Show" | Herself (1 episode, 2000) |
| "Famous Families" | Herself (1 episode, 1998) |
| "Family Guy" | Jillian |
| Riding in Cars with Boys | Beverly Donofrio |
| Skipped Parts | Fantasy Girl |
| Olive, the Other Reindeer | Olive (voice) |
| "Late Show with David Letterman" | Herself (5 episodes, 1996-2007) |
| Disneyland's 30th Anniversary Celebration | Herself |
| Freddy Got Fingered | Davidson's Receptionist |
| Hollywood: Wild in the Streets | Herself - Party footage |
| Donnie Darko | Karen Pomeroy |
| AFI's 100 Years, 100 Laughs: America's Funniest Movies | Herself |
| The Making of 'E.T. The Extra-Terrestrial' | Herself |
| Happy 100th Birthday, Hollywood | Herself |
| The 71st Annual Academy Awards | Herself - Audience Member |
| The 72nd Annual Academy Awards | Herself - Co-Presenter: Best Costume Design |
| Duplex | Nancy Kendricks |
| 100 Years of the Hollywood Western | Herself |
| Confessions of a Dangerous Mind | Penny |
| Who Is Alan Smithee? | Herself (archive footage) (uncredited) |
| The 70th Annual Academy Awards | Herself - Presenter: Best Makeup |
| Star Fairies | Hillary (voice) |
| Confessions of a Dangerous Mind | Penny |
| Charlie's Angels: Full Throttle | Dylan Sanders |
| 8th Annual Screen Actors Guild Awards | Herself (archive footage) |
| "HBO First Look" | Herself / ... (5 episodes, 2000-2007) |
| The Tom Green Cancer Special | Herself |
| Fever Pitch | Lindsey Meeks |
| Lucky You | Billie Offer |
| 2000 Blockbuster Entertainment Awards | Herself |
| 50 First Dates | Lucy Whitmore |
| The E.T. Reunion | Herself |
| The 61st Annual Academy Awards | Herself |
| Saturday Morning: Cartoons' Greatest Hits | Herself |
| 2003 MTV Movie Awards | Herself |
| E.T. the Extra-Terrestrial: 20th Anniversary Celebration | Herself |
| Live at the Shrine! John Williams and the World Premiere of 'E.T.: The Extra Terrestrial': The 20th Anniversary | |
| MTV Video Music Awards 2003 | Herself |
| "I Love the '70s" | Herself |
| My Date with Drew | Herself |
| Curious George | Maggie (voice) |
| Saturday Night Live: The Best of Will Ferrell | Barbara Hernandez (uncredited) (archive footage) |
| Angelic Attire: Dressing Cameron, Drew & Lucy | Herself |
| Getting G'd Up | Herself |
| The Master and the Angels | Herself |
| Family Guy Presents Stewie Griffin: The Untold Story | Herself (voice) |
| Behind the 'Scream' | Herself |
| "On-Air with Ryan Seacrest" | Herself / ... (2 episodes, 2004) |
| 101 Most Shocking Moments in Entertainment | #86 Drew Barrymore Deals with Drugs (archive footage) |
| "Extreme Close Up with ..." | Herself (1 episode) |
| The Making of 'Charlie's Angels: Full Throttle' | Herself |
| 2004 MTV Movie Awards | Herself - winner |
| Choose or Lose Presents: The Best Place to Start | |
| Choose or Lose Presents: The Best Place to Start | Herself |
| The Dating Scene | Herself |
| Ramones Raw | Herself |
| Reel Comedy: 50 First Dates | Herself |